The men were outside their cars on westbound Del Amo Boulevard when the woman, driving a Dodge Caravan, crashed into them, police said.
Eight other people, including five children, were also injured in the crash.
Bystanders said nobody was on the bus when it crashed and nobody appeared to be seriously injured.
The crash was on Spring Street just west of the 605 Freeway around 4:45 Wednesday morning, according to police.
The crash shut down Pacific Avenue in both directions around 12:40 p.m. while police investigated Tuesday afternoon.
Two people were hospitalized when their car smashed through a guardrail on a 710 Freeway onramp and fell about 75 feet to an access road below, according to Long Beach police.
The crash is close to being cleared up, an official said.
Two Long Beach Unified School District students we’re on board a charter bus that collided with a FedEx tractor-trailer in Orland, CA Thursday night which killed 10 people and injuring dozens more.
Coroner’s officials identified Sunday the motorist who died in a massive multi-vehicle crash that closed the 710 freeway for hours early Saturday morning.